This may be a no-brainer for some of you, but I loved this idea when I came across it (and likely wouldn’t have thought of it with mommy-brain):
I layer my crib sheets with protective pads so that I need only strip off the top layer and pad if/when the sheet gets soiled. When D first started sleeping longer at night, this was a lifesaver, as he would often wake because his diaper had leaked. I could whisk him out of the crib, do a quick diaper and sleeper change, and strip the top sheet and pad off; all done without completely waking from my semi-conscious state. This is also a great space saver if your linen storage is limited. I currently have three crib sheets layered on ‘in case of emergencies’.